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release date:2018.02.05

Pivotal role of sulfide catabolism in hypoxia tolerance

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【Speaker】Dr. Fumito Ichinose
【Affiliation】William Thomas Green Morton Professor of Anaesthesia,
Department of Anesthesia, Critical Care and Pain Medicine,
Massachusetts General Hospital, Harvard Medical School, Boston, MA
【Title】Pivotal role of sulfide catabolism in hypoxia tolerance 
【Time & Date】 17:00-18:00/ Friday, 9th March, 2018
【Venue】Seminar room 105, 1st floor, Biomedical Research Station, Hospital Campus
http://www.kyushu-u.ac.jp/f/30074/Hospital_en-2017.pdf

【Topics】
Hydrogen sulfide is an endogenous gas that inhibits mitochondrial electron transfer and energy production at low micromolar concentrations. Although hypoxia triggers sulfide production, role of sulfide in hypoxic response remains unknown. Here, we examined the impact of sulfide metabolism in the response to oxygen deprivation in the brain, the most sensitive organ to hypoxia. We observed that the brains of hypoxia-tolerant ground squirrels have a 10-fold greater capacity to oxidize sulfide than the brains of hypoxia-sensitive mice. Neuron-specific overexpression of sulfide:quinone oxidoreductase (SQR), the rate-limiting sulfide oxidation enzyme, prevented hypoxia-induced sulfide accumulation and depletion of adenosine triphosphate in brain and made mice resistant to hypoxia and cerebral ischemia. Similarly, administration of pharmacological sulfide scavengers maintained mitochondrial electron transfer in hypoxic neurons and prevented ischemic brain injury in mice. These results illuminate the pivotal role of sulfide catabolism in hypoxic energy failure of the mammalian brain. Sulfide catabolism may be harnessed to minimize hypoxic brain damage.

【References】
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— 
Yoji Andrew Minamishima, M.D., Ph.D.
Division of Cell Biology, Department of Molecular and Cellular Biology,
Medical Institute of Bioregulation, Kyushu University
3-1-1 Maidashi, Higashi-ku, Fukuoka, Fukuoka 812-8582, Japan
TEL: +81-92-642-6795, -6797, -6818
FAX: +81-92-642-6819
minamish@med.kyushu-u.ac.jp

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Yoji Andrew Minamishima, M.D., Ph.D.
Division of Cell Biology, Department of Molecular and Cellular Biology,
Medical Institute of Bioregulation
TEL: +81-92-642-6795
Mail: minamish★med.kyushu-u.ac.jp
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