KYUSHU UNIV GUIDE BOOK 2014_15_02 page 17/44

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KYUSHU UNIV GUIDE BOOK 2014_15_02

ATLAS detectorResearch Center for Advanced Particle PhysicsThe Research Center for Advanced Particle Physics was established in 2012 toserve as an international research and education center for advancedparticle physics. Its activities include experimental particle research throughaccelerator experiments, promotion of next-generation accelerationexperiments and theoretical particle physics research.New cancer treatment combining suppression of Fbxw7 protein and anticancer drugs (quiescence prevention treatment)Higgs boson candidates detected in the ATLAS experiment■ Promoting Big Sciencewith Advanced Particle Physics ResearchMedical Institute of BioregulationIn order to completely treat cancer, it had been necessary to eradicate thecancer stem cells that are the source of cancer cells, but because themechanism of long-term survival had not been clarified, there was not aneffective treatment method. The center discovered a protein called Fbxw7that holds the key to long-term survival cancer stem cells. Expectations arehigh for the development of a causal treatment for many types of cancers,including leukemia by blocking Fbxw7 capability.■ New Cancer Treatmentby Eradication of Cancer Stem CellsMG2G0(Quiescence)SCell Cycle G1Leukemia-initiatingcells no longerquiescentVery effectiveFbxw7 suppression andc-Myc accumulationinterrupt quiescenceLeukemia-initiatingcells in quiescenceNot effectiveAnticancerdrugsKYUSHU UNIVERSITY : DISCOVERY ｜ 17